GLYCOSAMINOGLYCAN-DEGRADING ENZYME INHIBITION AND RESULTANT DISEASE THERAPIES

摘要

Methods for the inhibition of glycosaminoglycan-degrading enzymes are described. These methods involve reacting glycosaminoglycan-degrading enzymes or cells producing the same with an oligonucleotide characterized in that at least one backbone linkage between adjacent nucleosides in the oligonucleotide is substituted with one or more sulphur atoms. Also described are methods for the treatment of disease associated with glycosaminoglycan-degrading enzymes.