发明名称 |
IMPROVED PROCESS FOR R (+) 1,2,3,6-TETRAHYDRO-4-PHENYL-1-[(3-PHENYL-3-CYCLOHEXEN-1-YL)METHYL]PYRIDINE, A CENTRAL NERVOUS SYSTEM AGENT |
摘要 |
An improved process for the preparation of R (+) 1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-yl)methyl]pyridine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operations to the desired product, as well as processes for the resolution of 5-oxo-3-phenyl-3-cyclohexenecarboxylic acid using cinchonidine to afford (S) 5-oxo-3-phenyl-3-cyclohexenecarboxylic acid or alpha -chymotrypsin to selectively hydrolyze <u>n</u>-butyl 5-oxo-3-phenyl-3-cyclohexenecarboxylate to afford (S) 5-oxo-3-phenyl-3-cyclohexenecarboxylic acid as well as other valuable intermediates used in the processes.
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申请公布号 |
WO9608473(A1) |
申请公布日期 |
1996.03.21 |
申请号 |
WO1995US09511 |
申请日期 |
1995.07.28 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
BUTLER, DONALD, EUGENE;GAILEY, JODETTE;LE, TUNG, VAN;SMITH, WILLIAM, JOHN, III;WUSTROW, DAVID, JUERGEN |
分类号 |
C07C51/48;C07C51/487;C07C61/39;C07C62/38;C07C69/757;C07D211/70;C07D453/04;(IPC1-7):C07D211/70 |
主分类号 |
C07C51/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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