A process for amidating a compound having a structural nucleus of formula (A) by reaction with an amine, to form the corresponding ring-opened amide, is modified by the addition of an additive that accelerates the rate of reaction to an extent that the reaction can be carried out at atmospheric pressure.
申请公布号
WO9608465(A1)
申请公布日期
1996.03.21
申请号
WO1995GB02183
申请日期
1995.09.12
申请人
CHIROSCIENCE LIMITED;BANNISTER, ROBIN, MARK;HENDERSON, NEIL;RUECROFT, GRAHAM
发明人
BANNISTER, ROBIN, MARK;HENDERSON, NEIL;RUECROFT, GRAHAM