发明名称 |
CORTICOTROPIN RELEASE INHIBITING FACTOR AND METHODS OF USING SAME |
摘要 |
The invention features a substantially pure preparation of a peptide having corticotropin release inhibiting factor (CRIF) activity comprising at least three contiguous amino acids contained within the amino acid sequence positioned between the fourth and fifth thyrotropin releasing hormone (TRH) sequence on a prepro-TRH protein. The CRIF peptide further comprises the fourth uncleaved TRH portion of prepro-TRH positioned at the amino terminus of CRIF. Compositions, methods of diagnosis and methods of treating CRIF related diseases are also included in the invention.
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申请公布号 |
CA2199734(A1) |
申请公布日期 |
1996.03.21 |
申请号 |
CA19952199734 |
申请日期 |
1995.09.08 |
申请人 |
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (THE) |
发明人 |
REDEI, EVA;AIRD, FRASER |
分类号 |
A61K38/00;C07K14/575;C07K16/26;(IPC1-7):C12N15/16;A61K38/03;C07K4/12;A61K31/195;A61K38/22;A61K39/395;G01N33/53;C12Q1/68;A61K31/70 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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