4-(4-METHANESULFONAMIDOPHENYL)BUTYLAMINE DERIVATIVES WITH ANTIARRHYTHMIC ACTIVITY

摘要

Methanesulfonamides are structurally depicted by formula (I), or its pharmacologically acceptable salts where R3 is a C1-7 alkyl substituted with C3-7 cycloalkyl, or a C1-10 alkyl substituted with one to eight fluorine atoms, one to three hydroxy, one to three C1-5 acyloxy or one to three C1-4 alkoxy substituents. These compounds are useful as Class III antiarrhythmic agents and are stable against rapid metabolism. Methods for treating cardiac arrhythmias with the compounds of formula (I) as well as compositions thereof are also described.