发明名称 |
PHARMACEUTICAL COMPOSITIONS CONTAINING D2O |
摘要 |
A pharmaceutical composition comprises a solution or suspension of a biological agent in a diluent comprising D2O, which solution or suspension contains sufficient amounts of a sugar, phosphate, glutamic acid or a physiologically acceptable salt thereof and, optionally, a non-toxic protein, a peptone or a mixture of two or more amino acids besides glutamic acid to enhance the stability of the agent. Typically, the composition is a suspension of a live attenuated poliovirus or an inactivated poliovirus of each of poliovirus types 1, 2 and 3. Preferably the solution or suspension contains stabilising amounts of sucrose, KH2PO4, K2HPO4, L-glutamic acid or sodium glutamate and human serum albumin (SPGA).
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申请公布号 |
WO9608273(A1) |
申请公布日期 |
1996.03.21 |
申请号 |
WO1995GB02190 |
申请日期 |
1995.09.15 |
申请人 |
MEDEVA EUROPE LIMITED;FURMINGER, IAN, GEORGE, STEPHEN;SIZER, PHILIP, JAMES |
发明人 |
FURMINGER, IAN, GEORGE, STEPHEN;SIZER, PHILIP, JAMES |
分类号 |
A61K9/107;A61K39/12;A61K39/13;A61K47/02;(IPC1-7):A61K47/02 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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