发明名称 |
ANTI-RECEPTOR AND GROWTH BLOCKING AGENTS TO THE VITAMIN B12/TRANSCOBALAMIN II RECEPTOR AND BINDING SITES |
摘要 |
There is disclosed anti-receptor and growth blocking agents to the vitamin B12/transcobalamin II receptor and binding sites. The anti-receptor and growth blocking agents antagonize or modulate the vitamin B12/transcobalamin II receptor or binding sites, causing cellular depletion of vitamin B12, thus inhibiting cell division or causing apoptosis. Anti-receptor and growth blocking agents of the present invention include proteins (such as antibodies and antibody derivatives), peptides and small organic molecules.
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申请公布号 |
WO9608515(A1) |
申请公布日期 |
1996.03.21 |
申请号 |
WO1995US12207 |
申请日期 |
1995.09.13 |
申请人 |
RECEPTAGEN CORPORATION;STATE UNIVERSITY OF NEW YORK |
发明人 |
MORGAN, A., CHARLES, JR.;QUADROS, EDWARD, V.;ROTHENBERG, SHELDON, P. |
分类号 |
C12N15/02;A61K38/00;A61K39/395;A61K45/00;A61P3/02;A61P35/00;A61P43/00;C07K16/18;C07K16/28;C12N5/10;C12P21/08;C12R1/91;(IPC1-7):C07K16/18 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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