发明名称 |
CLOTRIMAZOLE METABOLITES IN THE TREATMENT OF SICKLE CELL DISEASE |
摘要 |
The present invention provides methods and products for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling. The compounds useful according to the invention are derivatives of imidazoles that are antimycotics, including clotrimazole, miconazole, econazole, butoconazole, oxiconazole and sulconazole. Such analogs are active in the methods of the invention, despite the fact that they do not contain an imidazole group. |
申请公布号 |
WO9608242(A2) |
申请公布日期 |
1996.03.21 |
申请号 |
WO1995US11822 |
申请日期 |
1995.09.15 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
BRUGNARA, CARLO;RAFAI, NADER;PLATT, ORAH |
分类号 |
A61K31/03;A61K31/05;A61K31/075;A61K31/085;A61K31/10;A61K31/15;A61K31/381 |
主分类号 |
A61K31/03 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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