发明名称 SELECTIVE BLOCKING OF SPONTANEOUSLY-ACTIVE DOPAMINE NEURONESIN VENTRAL TEGMENTAL AREA
摘要 Psychoses in human beings is treated by administering an effective amount of the compound 5-chloro-1-(4-fluorophenyl)-3-(1-(2-(2-imidazolidinon-1-yl)ethyl)-4-piperidyl)-lH-indole, or a pharmaceutically acceptable salt thereof, to a patient in need thereof, the compound selectively blocks dopamine neurones in the ventral teqmental area of the brain, substantially without blocking the dopamine neurones in the substantia niqra pars compacta and, therefore, is free from the extrapyramidal side effects of common neuroleptics.
申请公布号 CA2014208(C) 申请公布日期 1996.03.19
申请号 CA19902014208 申请日期 1990.04.09
申请人 H. LUNDBECK A/S 发明人 PERREGAARD JENS;SKARSFELDT, TORBEN
分类号 C07D401/14;A61K31/33;A61K31/4427;A61K31/445;A61P25/00;A61P25/18;A61P43/00;(IPC1-7):A61K31/445 主分类号 C07D401/14
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