摘要 |
A peptide of formula: A-D-Mrp-Ala-B-C where A is any L-amino acid present in nature or its D isomer with the exception that it is not His if B is Trp and C is D-Phe-Lys-NH2, imidazole acetyl, Glu-Tyr-Ala- His, Tyr-Ala-His, Tyr-His, D-Thr-His and more preferably A is D-Ala, D-Thr, Tyr; D refers to the dextrorotatory isomer, Mrp is 2-alkyltryptophan, B is Trp or Phe, C is NH2, D-Phe-LysNH2, D-Trp-LysNH2, D-Phe-Lys-ThrNH2, D-Phe- Lys-D-ThrNH2, and the addition salts of any of the said polypeptides with pharmaceutically acceptable organic or inorganic acids, these compounds being able to promote the release of growth hormone, and being active via the oral route. |