发明名称 |
PERCUTANEOUS ABSORPTION PREPARATION |
摘要 |
A percutaneous absorption preparation for use in the administration of isosorbide dinitrate (ISDN) as a coronary vasodilator into the living body by percutaneous absorption, which has excellent adhesion to the skin and does not cause pain and damage to stratum corneum when peeled off, is disclosed. The pressure-sensitive adhesive layer comprises an acrylic copolymer prepared by copolymerization of a monomer mixture comprising a (meth)acrylic acid alkyl ester and a functional monomer as the essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms, and ISDN, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of ISDN is improved and the area of the preparation can be decreased.
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申请公布号 |
CA2157754(A1) |
申请公布日期 |
1996.03.15 |
申请号 |
CA19952157754 |
申请日期 |
1995.09.07 |
申请人 |
NITTO DENKO CORPORATION;TOA EIYO LTD. |
发明人 |
AKEMI, HITOSHI;MURAOKA, TAKATERU;HIGASHIO, KAZUHIRO;OTSUKA, SABURO;KINOSHITA, TAKASHI |
分类号 |
A61K9/70;A61K31/34;A61K47/14;A61P9/08;A61P9/10;(IPC1-7):A61K9/70;A61K47/30 |
主分类号 |
A61K9/70 |
代理机构 |
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主权项 |
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