发明名称 |
Retrovirus-like particles made non-infectious by a plurality of mutations |
摘要 |
Non-infectious, retrovirus-like particles contain mutations to reduce gag-dependent RNA-packaging of the gag gene product, eliminate reverse transcriptase activity of the pol gene product, eliminate integrase activity of the pol gene product and eliminate RNase H activity of the pol gene product through genetic manipulation of the gag and pol genes. The corresponding nucleic acid molecules are described. The non-infectious, retrovirus-like particles have utility in in vivo administration including to humans and in diagnosis. |
申请公布号 |
AU3249195(A) |
申请公布日期 |
1996.03.14 |
申请号 |
AU19950032491 |
申请日期 |
1995.08.22 |
申请人 |
CONNAUGHT LABORATORIES LIMITED |
发明人 |
BENJAMIN ROVINSKI;SHI-XIAN CAO;FEI-LONG YAO;ROY PERSSON;MICHEL H KLEIN |
分类号 |
A61K39/00;A61K39/21;A61K48/00;A61P31/18;C07K14/08;C07K14/16;C12N7/00;C12N7/04;C12N15/867 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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