Neue tricyclischen Steroid-Analogen

摘要

Novel tricyclic steroid analogs are disclosed which are 1H-benz[e]indene dodecahydro compounds that are useful for enhancing GABA-induced chloride currents at the GABA receptor/chloride ionophore complex and can be represented by the following structural formulas: wherein R1 = H or C1-C4 alkyl or fluoroalkyl; R2 = H or C1-C4 alkyl or fluoroalkyl, in which R1 and R2 can be the same or different; R3 = H or CH3; R4 = H or CH3, in which R3 and R4 can be the same or different; R5 = H; R6 = H; R5,R6 = =O(carbonyl); R7 = H; R8 = a hydrogen bond accepting group. R7,R8 = =O(carbonyl); and R' = an ester group.