发明名称 |
RETROVIRAL VECTOR HYBRIDS AND THE USE THEREOF FOR GENE TRANSFER |
摘要 |
The disclosure relates to replication defective retroviral vector hybrids characterized by the fact that they contain: ( a) in the leader region as U5 region and/or tRNA primer binding site, the U5 region and/or tRNA primer binding site of MESV; and (b) as U3 and R regions in 3'-LTR, the U3 and R regions from a Friend murine leukaemia virus (F-MuLV). The proposed hybrids are particularly suitable for effective gene transfer in haematopoietic stem cells.
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申请公布号 |
CA2199131(A1) |
申请公布日期 |
1996.03.14 |
申请号 |
CA19952199131 |
申请日期 |
1995.08.10 |
申请人 |
BOEHRINGER MANNHEIM GMBH |
发明人 |
BAUM, CHRISTOPHER;STOCKING-HARBERS, CAROL;OSTERTAG, WOLFRAM |
分类号 |
C12N15/09;A61K35/76;A61K48/00;A61P35/00;C07H21/04;C07K14/705;C12N5/10;C12N15/867;(IPC1-7):C12N15/86;C12N7/01 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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