MONOCYTE CHEMOTAXIN INDUCIBLE PROTEINS

摘要

The present invention relates to the use of three novel peptides for the manufacture of a composition for the treatment of diseases, the pathogenesis of which is related to the decreased production and/or function of immuno-stimulating mediators, especially cytokines, e.g. IL-1, TNF, TNF gamma and MCAF/MCP-1, and/or is related to an increased production of immuno-inhibitory mediators, especially cytokines, e.g. IL-10, in particular a disease selected from the group consisting of immune-incompetence, such as HIV-infections, mononucleosis or other infections such as bacterial infections, e.g. Salmonella T. and Pseudomonas A., tendency of bleeding, cancer such as malignant melanoma, non-malignant disorders of growth, such as psoriasis, papillomas of the skin, the gastro-intestinal tract, and the vesical bladder, and growth disorders induced by viral infections such as common warts and condyloma accuminatum, both caused by human papilloma virus, and for use as adjuvants in connections with immunization. In particular, the invention relates to a peptide which has a molecular weight of about 17 kD and an isoelectric point of about 5.5 and a peptide which has a molecular weight of about 22 kD and an isoelectric point of about 5.0, both obtainable by two-dimensional gel electrophoresis where the IEF second dimension gel elctrophoresis is carried out using a stepwise gradient technique incorporating 20 % and 15 % SDS-PAGE running gels.