发明名称 |
Prepn. of substd. di:amino-di:carboxylic acid derivs. |
摘要 |
The prepn. of substd. diaminodicarboxylic acid derivs. of formula (I) by opt. mixed Kolbe synthesis comprises dissolving a protected amino acid derv. of formula (II) with a protected amino acid derv. of formula(III) in a solvent R<4>OH or in a heterocyclic or in a heterocyclic or aliphatic solvent contg. /- 1 hetero atom, or in an mixt. of such solvents, subjecting the soln. to electrolysis with Pt gauze electrodes and then opt. hydrolysing the prod. with LiOH. R<1> and R<2> = each opt. halogenated, linear, branched or cyclic 1-10C alkyl or COA or COOA; A = opt. halogenated, linear, branched or cyclic 1-10C alkyl, benzyl (opt. mono- or poly-substd. with halogen, NO2, alkoxy, and/or CN) or 9-fluorenylmethyl; R<3> = linear or branched 1-4C alkyl; the centres of chirality in (I) are determined by the educts used and are both L or both D or are D, L or L, D; n = 2-8; k and l are integers, such that k+l = n; R<4> = R<3>.
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申请公布号 |
DE4431119(A1) |
申请公布日期 |
1996.03.14 |
申请号 |
DE19944431119 |
申请日期 |
1994.09.01 |
申请人 |
NYCOMED ARZNEIMITTEL GMBH, 85737 ISMANING, DE |
发明人 |
HIEBL, JOHANN, DR., PICHLING, AT;ROVENSZKY, FRANZ, DIPL.-ING. DR., LINZ, AT |
分类号 |
C07C227/16;C07C231/12;C07C269/06;C25B3/10;(IPC1-7):C07C229/26;C07C227/14;C07C229/24 |
主分类号 |
C07C227/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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