发明名称 |
Production in bacteria and yeast of hemoglobin and analogues thereof |
摘要 |
A method of producing a hemoglobin-like protein wherein an alpha globin-like polypeptide and a beta globin-like polypeptide are each expressed in transformed non-erythrocyte cells such as bacterial or yeast cells, the method comprising expressing the alpha and beta globin-like polypeptide in the same cell in such manner that the alpha and beta globin-like polypeptides are assembled and combined with heme so as to intracellularly produce a biologically functional hemoglobin-like protein in soluble, recoverable form. <MATH> |
申请公布号 |
EP0700997(A1) |
申请公布日期 |
1996.03.13 |
申请号 |
EP19950110064 |
申请日期 |
1990.05.10 |
申请人 |
SOMATOGENETICS INTERNATIONAL, INC. |
发明人 |
HOFFMANN, STEPHEN J.;LOOKER, DOUGLAS L.;ROSENDAL, MARY S.;STETLER, GARY L.;WAGENBACH, MICHAEL |
分类号 |
C07K19/00;A61K38/00;A61K47/48;C07K14/00;C07K14/805;C12N15/09;C12N15/12;C12N15/81;C12P21/02;C12R1/19;C12R1/865;G01N33/53 |
主分类号 |
C07K19/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|