摘要 |
The new naphthamide derivatives according to the invention are characterized in that they correspond to the general formula (I), <IMAGE> (I) where X: represents either a hydrogen atom, or a chlorine or bromine atom, or an amino or aminoalkyl group, an aminosulphamoyl group, a sulphur-containing group such as thiocyanate, alkylthio, alkylsulphinyl or alkylsulphonyl, or a methoxy group, or a nitro group, or a cyano group, or an electron-attracting group; Y: represents an alkyl or alkenyl residue; Z: represents the residues originating from 2-aminomethyl-N-alkylpyrrolidine, 2-aminoethyl-N,N-diethylamine, 2-(aminoethyl)morpholine, 2-aminoethyl-N,N-dibutylamine, 4-amino-N-butylpiperidine or 2-(aminoethyl)pyrrolidine; R: a hydrogen or an OCH3 substituent. These new derivatives may be employed in the preparation of medicinal products intended for use as an antipsychotic, psychostimulatory, anti-autistic or antidepressant agent, an agent for treating Parkinson's disease or an antihypertensive agent.
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申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
发明人 |
ROGNAN, DIDIER;MANN, ANDRE;WERMUTH, CAMILLE-GEORGES;MARTRES, MARIE-PASCALE;GIROS, BRUNO;SOKOLOFF, PIERRE;SCHWARTZ, JEAN-CHARLES;LECOMTE, JEANNE-MARIE;GARRIDO, FABRICE |