发明名称 |
Substantially pure enantieners of 2-azabicyclo(2.2.1)hept-5-en-3-one |
摘要 |
Lactams of 1-amino-3-carboxylic acid cyclic compounds are produced in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic lactam with a novel lactamase. The products are useful in the synthesis of chiral carbocyclic nucleotides. The enantiomer is preferrably 2-azabicyclo(2.2.1)hept-5-en-3-one. It is desirable to isolate the enantiomer comprising predominantly the (+) enantiomer and a residual amount of the (-) enantiomer, wherein the (+) enantiomer is present in an enantiomeric excess of at least about 88% over the (-) enantiomer or the enantiomer comprising predominantly the (-) enantiomer and a residual amount of the (+) enantiomer, wherein the (-) enantiomer is present in an enantiomeric excess of at least about 98% over the (+) enantiomer.
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申请公布号 |
US5498625(A) |
申请公布日期 |
1996.03.12 |
申请号 |
US19940336754 |
申请日期 |
1994.11.08 |
申请人 |
CHIROSCIENCE LIMITED |
发明人 |
EVANS, CHRISTOPHER T.;ROBERTS, STANLEY M. |
分类号 |
C12N9/86;C07D209/52;C07D491/08;C07D498/04;C07D498/08;C12N1/20;C12P13/00;C12P17/10;C12P41/00;C12R1/01;(IPC1-7):A01N43/38;C07C7/00;C12N9/78;C07D207/12 |
主分类号 |
C12N9/86 |
代理机构 |
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主权项 |
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地址 |
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