4-amino-N-(4-methyl-4-piperidinyl)-2-methoxybenzamides for treating smooth muscle contraction disorders

摘要

PCT No. PCT/EP93/01993 Sec. 371 Date Jan. 6, 1995 Sec. 102(e) Date Jan. 6, 1995 PCT Filed Jan. 6, 1995 PCT Pub. No. WO94/02462 PCT Pub. Date Feb. 3, 1994.Piperidinyl substituted benzamides of formula cid addition salts thereof and the stereoisomeric forms thereof, wherein R1 is hydrogen or halo; R2 is halo; R3 is hydrogen or halo; R4 and R5 each independently are hydrogen, C1-4alkyl or haloC1-4alkyl; and the group NR4R5 may also be azido, Alk is C2-4alkanediyl; pharmaceutical compositions containing said compounds of formula (I) as active ingredient; use of said compounds as a medicine; process of preparing said compounds; compounds of formula (I) containing a radioactive isotope; process of marking 5HT2-receptor sites; and process for imaging an organ are disclosed.