| 摘要 |
Antibiotics 47,433 and 47,434 are produced by culture of Actinomycete micro-organism ATCC 31286, and are useful for controlling coccidiosis in poultry by administration in the diet, and for improving feed utilisation in ruminants and monogastric animals. …<??>Antibiotic 47,433 as crystalline free acid is soluble in methanol, acetone, chloroform, methylisobutyl ketone, ethyl acetate and insoluble in water; m.p. 89-99 DEG C; ( alpha )D = +16 DEG (C = 1.0, MeOH); average composition by weight: 64.92% carbon, 9.73% hydrogen and 25.35% oxygen (by difference); infrared absorption (KBr pellets, in microns):2.87, 3.42, 5.77, 6.85, 7.30, 8.05, 8.60, 9.20, 10.15, 10.53 and 11.45; following crystalline salts are described: -Na(m.p. 226-32 DEG ; ( alpha )D = -0.2 DEG (C = 1.0, MeOH), -K (m.p. 202.-5 DEG ; ( alpha )D = -3.2 (C = 1.0, MeOH), -Ag (m.p. 180-2 DEG ; ( alpha )D = +3.6 DEG (C = 1.0, MeOH). Antibiotic 47.434 as crystalline sodium salt is soluble in chloroform, ethyl acetate, methylisobutyl ketone and insoluble in water; m.p. 230-238 DEG C, ( alpha )D = -1.3 DEG (C = 1.0, MeOH); infra-red absorption (KBr pellets, in microns): 3.40, 6.40, 6.85, 7.14, 7.27, 7.75, 8.05, 8.40, 8.62, 9.10, 9.40, 10.07, 10.50, 11.49, 12.65 and 13.25. |
