发明名称 |
Water-soluble polyene conjugate |
摘要 |
A method for producing a substantially stable water-soluble polysaccharide conjugate of a polyene antibiotic is described. The method comprises the following steps: (a) activating the polysaccharide to a dialdehyde by periodate oxidation; (b) purifying the dialdehyde from interfering anions and by-products; (c) coupling the polyene to the purified dialdehyde by Schiff base formation to form the conjugate; and (d) purifying the conjugate. In a preferred embodiment, the conjugate of step (c) is reduced to an amine conjugate by a reducing agent prior to purification. Also described are imine and amine polysaccaride conjugates of the polyene Nystatin. |
申请公布号 |
AU3367395(A) |
申请公布日期 |
1996.03.07 |
申请号 |
AU19950033673 |
申请日期 |
1995.08.16 |
申请人 |
HELFGOTT & KARAS, P.C.;YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF |
发明人 |
GALINA LINDEN;ABRAHAM J. DOMB;ITZHACK POLACHECK;SHIMON BENITA |
分类号 |
A61K47/48;C08B37/00;C08B37/02 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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