IMPROVEMENTS IN PRODUCTION OF PROTEINS IN HOST CELLS
摘要
Method of increasing protein production in a host cell where the nucleic acid encoding the protein has an A and/or T rich region in an exon. The method comprising lowering the amount of A and/or T rich region and transfecting a host cell with the altered nucleic acid and obtaining expression of the nucleic acid. The invention also relates to the recombinant nucleic acid constructs, purified protein preparations and pharmaceutical compositions produced as well as methods of treatment utilizing the purified protein preparation.
申请公布号
WO9606937(A1)
申请公布日期
1996.03.07
申请号
WO1995AU00553
申请日期
1995.08.30
申请人
THE AUSTIN RESEARCH INSTITUTE;MILLAND, JULIE;LOVELAND, BRUCE;CHRISTIANSEN, DALE;MCKENZIE, IAN, F., C.
发明人
MILLAND, JULIE;LOVELAND, BRUCE;CHRISTIANSEN, DALE;MCKENZIE, IAN, F., C.