GENETIC THERAPY OF VASCULAR DISEASES WITH A CELL-SPECIFIC ACTIVE SUBSTANCE WHICH IS DEPENDENT ON THE CELL CYCLE

摘要

A DNA sequence is disclosed for the genetic therapy of vascular diseases. The essential components of the DNA sequence are the activator sequence, the promoter module and the active substance coding gene. The activator sequence is specifically activated in smooth muscle cells, activated endothelial cells, activated macrophages or activated lymphocytes. Activation is cell cycleregulated by the promoter module. The active substance represents an inhibitor of the growth of smooth muscle cells and/or coagulation. The disclosed DNA sequence is inserted into a viral or non-viral vector, supplemented with a ligand with affinity for the target cells.