Carboxylic acid ester protecting groups, process to prepare them, their coupling to functional groups and their use

摘要

Carboxylic acid esters of polar hydrophilic alcohols, of the formula in which R is an unbranched or branched organic radical which contains as polar members between aliphatic or araliphatic hydrocarbon bridges ether oxygens, amine nitrogen groups or a mixture of ether and amine groups, which can be linked in a cyclic structure, where the total length is not greater than 20 members, in the case of polyethylene glycol [(CH2-CH2-O)n] n indicates the number of members and is defined as an integer of any desired size, and R' is an aliphatic or araliphatic radical which has at least one functional group, are suitable as protective groups because they can be introduced selectively into functional groups of organic compounds and can be specifically eliminated by lipases.