发明名称 |
METHOD OF MANUFACTURING THE CYCLOHEPTIMIDAZOLE DERIVATIVES |
摘要 |
Disclosed is a method in which a compound of general formula (1) is reacted with a compound of general formula (2), followed by deprotection of protective group Z to give the cycloheptimidazole derivative (4) wherein R1 is hydrogen or isopropyl; R2 is a lower alkyl; A and A1 are each a substituent at the 4- or 8-position, A1 is hydrogen or hydroxyl when A is a hydrogen or A and A1 together form an oxo group or =CHCOOR3 (R3 represents a lower alkyl); the dotted line means two double bonds or saturated single bonds; X is halogen atom or trifluoromethanesulfonate group; Y is B (OH) 2 or -Sn (R5) 3 (R5 represents a lower alkyl group). The cycloheptimidazole derivative (4) is useful as antihypertensive agent. <IMG> ( 1 ) <IMG> (2) (4) <IMG>
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申请公布号 |
CA2156121(A1) |
申请公布日期 |
1996.03.06 |
申请号 |
CA19952156121 |
申请日期 |
1995.08.15 |
申请人 |
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发明人 |
TOMIYAMA, TSUYOSHI;TOMIYAMA, AKIRA;YANAGISAWA, TAKASHI |
分类号 |
A61K31/415;A61P9/00;A61P9/12;A61P43/00;C07D235/02;C07D403/10;(IPC1-7):C07D403/10;C07F7/22;C07F5/02 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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