METHOD OF PREPARATION(-)-N-METHYL-N-£4-(4-PHENYL-4- -ACETYLAMINO-PIPERIDINE-1-YL)-2-(3,4-DICHLORPHENYL ) BUTYL| BENZAMIDE AND ITS PHARMACEUTICAL ACCEPTABLE SALTS

摘要

A process is described for the preparation of (+)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine of formula (I) and for the preparation of the (-)-N-methyl-N-[4-(4-phenyl-4-acetylamino-piperidin-1-yl)- -2-(3,4-dichlorophenyl)butyl]benzamide and of its pharmaceutically acceptable salts using the compound of formula (I) as synthesis intermediate.