| 摘要 |
PURPOSE: To simply obtain a large amount of an optically active endo-2- norborneol useful as a synthetic intermediate for medicines, etc., by asymmetri cally hydrolyzing a racemic endo-2-acyloxynorbornane with a lipase derived from the genus Candida. CONSTITUTION: This method for producing an optically active (S)-endo-2- norborneol of formula IV is to asymmetrically hydrolyze a racemic endo-2- acyloxynorbornane of formula I (R is a 1-22C straight-chain or branched alkyl, alkenyl, a cycloalkyl, an aralkyl or an aryl) with a lipase derived from the genus Candida as an origin such as Candida antarctica, produce a mixture of (R)-endo-2-norborneol of formula II with (S)-endo-2-acyloxynorbornane of formula III and hydrolyze the optically active acyloxynorbornane of formula III under acidic or basic conditions. |
