CEPHEM COMPOUND, ITS PRODUCTION AND ANTIMICROBIAL AGENT

摘要

PURPOSE: To obtain a new cephem compound capable of exhibiting excellent antimicrobial action and orally absorbing property and useful as an antimicrobial agent. CONSTITUTION: A compound of formula I [R<1> is an amino which may be protected; Q is N or CH; R<2> is H or a substitutable hydrocarbon; A is a substitutive heterocycle; (m) is 2 or 3; (n) is 0-3], e.g. p-methoxybenzyl 7β-[2(2- aminothiazol-4-yl)-2(Z)-trityloxyiminoacetamide]-3-[2-(2-pyrazinylthio )-ethyl]-3- cephem 4 carboxylate. The compound of formula I is obtained by reacting a 7-amino compound of formula II with a carboxylic acid of formula III or its reactive derivative in a solvent (e.g. THF) at -80 deg.C to 150 deg.C. This compound has strong antimicrobial action on both of gram-positive and gram-negative bacteria and is useful for preventing and treating sinopulmonary infectious diseases and urinary tract infectious diseases.