| 摘要 |
PURPOSE: To obtain a new peptide containing a specific amino aicd sequence obtained from bovine brain, etc., having prolylendopeptidase inhibiting activity, useful as a reagent for studies and metabolism improver, etc., a physiologically functional food and an animal feed and used for treating and preventing dementia. CONSTITUTION: This new peptide can be obtained from bovine brain, etc., and contains a specific amino acid sequence and has amino acid sequences expressed by formulas I to VIII and has prolylendopeptitase inhibiting activity, and is useful as a reagent for studies and metabolism improver, etc., and useful as a prolylendopeptidase inhibitor for treating and preventing diseases such as dementia in which prolylendopeptidase plays a role and useful also as a component for physiologically functional foods and feeds for animals. The peptide is obtained by grounding bovine brain, etc., in frozen state, charging the ground brain, etc., in a frozen state, charging the ground brain into hot water, homogenizing the ground brain, centrifuging the homogenized material and purifying the resultant supernatant by ultrafilter membrane, gel permeation, ion exchange chromatography and high-performance liquid chromatography using a reserve phase column, etc. |
