发明名称 |
Process for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia in vertebrates |
摘要 |
A process for the long-term modification and regulation of lipid metabolism-generally to reduce obesity, insulin resistance, and hyperinsulinemia (the three hallmarks of Type II diabetes)-by injections into the bloodstream of a vertebrate, animal or human, of prolactin, or both prolactin and a glucocorticosteroid. The injections are made over a limited period at a time of day dependent on the normal circadian rhythm of fat and lean members of a similar species. Decreases (or increases) in body fat deposits result by treatment of an obese species (lean species) on a daily timed sequence based on circadian rhythms of the peak prolactin, or peak prolactin and peak glucocorticosteroid, blood level established for lean members (or obese members) of a similar species. Insulin resistance, and hyperinsulinemia can also be controlled in humans on a long-term basis by treatment corresponding to that of the treatment for obesity. The short-term daily injections reset hormonal timing in the neural centers of the brain to produce long-term effects.
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申请公布号 |
US5496803(A) |
申请公布日期 |
1996.03.05 |
申请号 |
US19940287066 |
申请日期 |
1994.08.08 |
申请人 |
LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE |
发明人 |
MEIER, ALBERT H.;CINCOTTA, ANTHONY H. |
分类号 |
A61K31/00;A61K31/13;A61K31/15;A61K31/166;A61K31/195;A61K31/221;A61K31/35;A61K31/352;A61K31/40;A61K31/405;A61K31/435;A61K31/439;A61K31/445;A61K31/4515;A61K31/454;A61K31/46;A61K31/475;A61K31/48;A61K31/496;A61K31/54;A61K31/5415;A61K31/55;A61K31/551;A61K31/5513;A61K31/695;A61K38/22;A61K45/00;A61K45/06;A61P3/08;A61P3/10;C07D457/00;C07D457/04;G01N33/74;(IPC1-7):C07K14/64;C07K9/00;A61K38/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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