Cocaine receptor binding ligands

摘要

Novel compounds show high affinity for specific cocaine receptors in the brain, particularly dopamine transporter sites, and have the formula <IMAGE> Wherein Y=CONRR2, R1=hydrogen, C1-5 alkyl, X=H, C1-6 alkyl, C3-8 cycloalkyl, C1-4 alkoxy, C1-6 alkynyl, halogen, amino, acylamido, R and R2 may be saturated or unsaturated substituents of 1-6 carbon atoms, aromatic, or combine to form pyrrolidinyl, morpholinyl or piperidinyl moieties, and Z=H, I, Br, Cl, F, CN, CF3 NO2, N3, OR1, CO2NH2, CO2R1, C1-6 alkyl, NR4R5, NHCOF5, NHCO2R6, wherein R4-R6 are each C1-6 alkyl.