5-substituted tetrahydrobenzimidazole compounds

摘要

A process is provided for preparing a tetrahydrobenzimidazole derivative represented by Formula (Ib): <IMAGE> (Ib) wherein Het representa s heterocyclic group which may be substituted with 1 to 3 substituents selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl-lower alkyl group, an aralkyl group, a lower alkoxycarbonyl group, and a halogen atom; and X2 represents a single bond connected to the carbon atom of the heterocyclic ring as represented by Het. The process comprises reacting a heterocyclic compound represented by Formula (IIIa): Het-X2-H (IIIa) wherein Het and X2 are as defined above, with a carboxylic acid represented by Formula (II): <IMAGE> (II) or a reactive derivative thereof.