| 摘要 |
<p>PURPOSE: To industrially advantageously obtain the subject compound useful as a medicine by hydroxylating L-isoleucine and coupling the product with a specific amine derivative. CONSTITUTION: This method for producing a compound of formula V is to hydroxylate L-isoleucine of formula I, subject the resultantα-hydroxycarboxylic acid of formula II to coupling with an amine derivative of formula III [R<3> to R<5> are each H, a lower alkyl, a (substituted)aryl or a (substituted)arylalkyl; R<2a> is a carboxylic acid-protecting group], provide anα-hydroxycarboxylic amide derivative of formula IV and, as necessary hydrolyze the resultant derivative of formula IV.</p> |
