| 摘要 |
The compounds of the formula, <IMAGE> wherein the ring A is a pyrrole ring which may be hydrogenated; -B- is a divalent cyclic or chain group which may be substituted; one of Q1 and Q2 is N, with the other being N or CH; W is a halogen or hydrogen atom or a group bonded to the bonding line with a carbon, nitrogen, oxygen or sulfur atom, provided that W is not -NH2; X is an amino, hydroxyl or mercapto group; Y is a hydrogen atom or a hydroxyl or amino group; Z is a straight-chain divalent group having a number of atoms of 2 to 5 composed of carbon atoms which each may be substituted, or carbon atoms which each may be substituted and one hetero atom which may be substituted; -COOR1 and -COOR2 each is the same as or different from the other and represents a carboxyl group which may be esterified, or salts thereof are provided. The compounds are produced by reacting compounds of the formula, <IMAGE> wherein A, -B-, W, W, X, Y, Q1 and Q2 are the same as defined above, with compounds of the formula, <IMAGE> wherein -COOR1 and -COOR2 are the same as defined above, and useful as anti-tumor agents.
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