发明名称 |
Cells bearing cd4 decoy receptors and related molecules and methods |
摘要 |
Disclosed is a method of treating HIV in a mammal involving administering to the mammal an effective amount of therapeutic cells expressing a membrane-bound, proteinaceous chimeric receptor comprising an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection. Also disclosed are cells which express these CD4 receptors and DNA and vectors encoding the receptors. |
申请公布号 |
AU3201495(A) |
申请公布日期 |
1996.03.04 |
申请号 |
AU19950032014 |
申请日期 |
1995.07.26 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
BRIAN SEED;BABAK BANAPOUR;CHARLES ROMEO;WALDEMAR KOLANUS |
分类号 |
C12N15/09;A01N63/00;A61K35/14;A61K38/00;A61P31/18;C07K14/725;C07K14/73;C07K19/00;C12N5/10 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|