Production of 1,2,3-triazoles by cyclocondensation of hydrazides with glyoxal and amines

摘要

A high purity triazole is obtained by the reaction of a hydrazide of the general formula II and glyoxal followed by the treatment of the intermediate of general formula IV with ammonia. The total process is done in one pot and does not require the isolation of the intermediate IV. The triazole (I) is isolated by distillation. Synthesis of various N1-substituted triazoles is also described following the same procedure.