发明名称 Substituted o?6Õ-benzylguanines and 6(4)-benzyloxypyrimidines
摘要 The present invention provides AGT inactivating compounds such as substituted O<6>-benzylguanines, 7- or 9-substituted 8-aza-O<6>-benzylguanines, 7,8-disubstituted O<6>-benzylguanines, 7,9-disubstituted O<6>-benzylguanines, 4(6)-substituted 2-amino-5-nitro-6(4)-benzyloxypyrimidines, and 4(6)-substituted 2-amino-5-nitroso-6(4)-benzyloxypyrimidines, as well as pharmaceutical compositions comprising such compounds along with a pharmaceutically acceptable carrier. The present invention further provides a method of enhancing the chemotherapeutic treatment of tumor cells in a mammal with an antineoplastic alkylating agent which causes cytotoxic lesion at the O<6>-position of guanine, by administering to a mammal an effective amount of one of the aforesaid compounds, 2,4-diamino-6-benzyloxy-s-triazine, 5-substituted 2,4-diamino-6-benzyloxypyrimidines, or 8-aza-O<6>-benzylguanine, and administering to the mammal an effective amount of an antineoplastic alkylating agent which causes cytotoxic lesions of the O<6>-postion of guanine.
申请公布号 AU3207995(A) 申请公布日期 1996.03.04
申请号 AU19950032079 申请日期 1995.07.31
申请人 THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY,;ARCH DEVELOPMENT CORPORATION;THE PENN STATE RESEARCH FOUNDATION, INC. 发明人 ROBERT C MOSCHEL;ANTHONY E PEGG;M. EILEEN DOLAN;MI-YOUNG CHAE
分类号 A61K31/505;A61K31/52;A61K31/522;A61K31/53;A61P35/00;A61P43/00;C07D239/46;C07D239/47;C07D239/48;C07D239/50;C07D251/52;C07D473/06;C07D473/18;C07D473/40;C07D487/04 主分类号 A61K31/505
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