DIHYGROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS

摘要

A compound of formula (I) and its pharmaceutically acceptable salts, wherein A<1> and A<2> are each halo; X is direct bond, CH2, CO, O, S, S(O) or S(O)2; R<1> is selected from a variety of groups such as hydrogen; substituted or unsubstituted C1-4 alkyl; substituted or unsubstituted piperidinyl; substituted or unsubstituted C5-14 cycloalkyl, bicycloalkyl or tricycloalkyl; substituted or unsubstituted C7-14 azacyclo-, azabicyclo- or azatricyclo-alkyl; bicyclo C7-10 alkenyl; benzocyclo C5-7 alkyl; and heterocyclic; R<2> is hydrogen, C1-4 alkyl, substituted or unsubstituted phenyl or heterocyclic; and R<3> and R<4> are each C1-5 alkyl. The novel dihydropyridine compounds of this invention have excellent bradykinin antagonistic activity and are thus useful for the treatment of inflammation, cardiovascular disease, pain, common cold, allergies, asthma, pancreatitis, burns, virus infection, head injury, multiple trauma or the like in mammalian, especially humans.