NEUROPROTECTIVE 3-(PIPERIDINYL-1)-CHROMAN-4,7-DIOL AND 1-(4-HYDROPHENYL)-2-(PIPERIDINYL-1)-ALKANOL DERIVATIVES

摘要

This invention relates to compounds of formula (I), or pharmaceutically acceptable acid addition salts thereof, wherein: (a) R<2> and R<5> are taken separately and R<1>, R<2>, R<3> and R<4> are each independently hydrogen, (C1-C6) alkyl, halo, CF3, OH or OR<7> and R<5> is methyl or ethyl; or (b) R<2> and R<5> are taken together, forming a chroman-4-ol ring, and R<1>, R<3> and R<4> are each independently hydrogen, (C1-C6) alkyl, halo, CF3, OH or OR<7>; and R<6> is a substituted piperidinyl, pyrrolidinyl or 8-azabicyclo(3.2.1)octanyl derivative; provided that (a) when R<2> and R<5> are taken separately, at least one of R<1>, R<2>, R<3> and R<4> is not hydrogen; and (b) when R<2> and R<5> are taken together, at least one of R<1>, R<3> and R<4> is not hydrogen; pharmaceutical compositions thereof; and methods of treating mammals suffering from stroke, spinal cord trauma, traumatic brain injury, multiinfarct dementia, CNS degenerative diseases such as Alzheimer's disease, senile dementia of the Alzheimer's type, Huntington's disease, Parkinson's disease, epilepsy, amyotrophic lateral sclerosis, pain, AIDS dementia, psychotic conditions, drug addictions, migraine, hypoglycemia, anxiolytic conditions, urinary incontinence and an ischemic event arising from CNS surgery, open heart surgery or any procedure during which the function of the cardiovascular system is compromised with a compound of formula (I) hereinabove or a pharmaceutically acceptable salt thereof.