摘要 |
The invention relates to a compound of the formula I <IMAGE> wherein the broken line represents an optional double bond; X is O, S, CH2 or CH2CH2; R1 is hydrogen, halogen, C1-C6 alkoxy, C1-C6 alkanoyl, C1-C6 alkyl or C1-C6 alkyl substituted with 1, 2 or 3 halogen atoms; R2 is phenyl, substituted phenyl, a heterocyclic group, or a substituted heterocyclic group, said substituted phenyl and substituted heterocyclic group being substituted with 1 or 2 substituents independently selected from the group consisting of C1-C6 alkyl, trifluoromethyl or halogen; R3 and R4 are each independently hydrogen, halogen, C1-C6 alkyl, or trifluoromethyl, or R3 and R4 taken together with a carbon atom, to which they are attached, form a six-membered carbocyclic aromatic ring, said aromatic ring being optionally substituted with 1 or 2 substituents selected from the group consisting of halogen, C1-C6 alkyl, and C1-C6 alkyl substituted with 1, 2 or 3 halogen atoms; and the pharmaceutically acceptable salts thereof. The compounds are useful in treating inflammation and other prostaglandin or leukotriene mediated diseases. |