PROCESS FOR PRODUCING L-LYSINE AND L-GLUTAMIC ACID BY FERMENTATION

摘要

L-glutamic acid is produced by imparting to a coryneform L-glutamate producing bacterium the temperature sensitivity with respect to biotin antagonists to prepare a variant capable of producing L-glutamic acid in a medium containing excessive biotin in the absence of a biotin antagonist and culturing the variant in a liquid medium. L-lysine and L-glutamic acid are produced at the same time by imparting to a coryneform L-glutamate producing bacterium the temperature sensitivity with respect to biotin antagonists and the ability to produce L-lysine to prepare a variant capable of producing L-lysine and L-glutamic acid in a medium containing excessive biotin in the absence of a biotin antagonist and culturing the variant in a liquid medium.