ANTIGENIC PEPTIDES DERIVED FROM THE G PROTEIN OF RSV FOR TYPE- AND SUBTYPE-SPECIFIC DIAGNOSIS OF RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION

摘要

Antigenic substance or precursor thereof comprising a peptide part derived from an amino acid sequence located between two mucin-like regions of a protein G of a respiratory syncytial virus (RSV). Said antigenic substance or precursor thereof allows to discriminate between, or identify, different types or subtypes of respiratory syncytial viruses, or antibodies against them. In preferred embodiments, the peptide part is derived from protein G of bovine respiratory syncytial virus, human respiratory syncytial virus A, human respiratory syncytial virus B, or ovine respiratory syncytial virus. Use of the antigenic substance or precursor thereof (in vaccines) for prophylaxis of RSV infections, in assays and testkits for detecting or identifying (antibodies against) RSV types or subtypes, and in methods for obtaining antibodies against RSV types or subtypes. Use of such antibodies in assays and testkits for detecting or identifying RSV types or subtypes.