| 摘要 |
<p>The invention provides for the use of immunoactive peptides (antigens) for active immunisation to produce antibodies which prevent 'triggering' of histamine release by mast cell degranulation and consequently inhibit carcinoma proliferation. The invention also provides for the use of antibodies for passive immunisation, which antibodies prevent 'triggering' of histamine release by mast cell degranulation and consequently inhibit carcinoma proliferation. The invention provides use of an immunogen comprising a covalent conjugate of a residue of a histamine-releasing peptide having a cationic N terminus and a hydrophobic C terminus, together with a residue capable of eliciting antibodies against this peptide in the manufacture of a medicament for the treatment of carcinomas, especially mammary adenocarcinomas. Preferably, the residue of a histamine-releasing peptide has the sequence Lys-Thr-Lys-Gly-Ser-Gly-Phe-Phe-Val-Phe (SEQ ID NO:1).</p> |
