发明名称 |
Crystalline esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
摘要 |
Crystalline acetoxymethyl and pivaloyloxymethyl esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo-[3.2.0]hept-2-ene-carboxylic acid can be obtained by adding a poor solvent to a solution of acetoxymethyl or pivaloyloxymethyl ester of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo-[3.2.0]hept-2-ene-carboxylic acid in a good solvent. The crystalline penem compounds obtained show improved stability and are useful antibacterial agents.
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申请公布号 |
US5492903(A) |
申请公布日期 |
1996.02.20 |
申请号 |
US19930112072 |
申请日期 |
1993.08.26 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES LTD. |
发明人 |
MAEDA, YOSHIHARU;ISHIBASHI, YUKIO;TSUKAMOTO, TETSUYA;MIZUNO, MASAHIRO |
分类号 |
C07D499/88;(IPC1-7):C07D499/00;A61K31/425 |
主分类号 |
C07D499/88 |
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