发明名称 |
Pharmaceutical formulations of nerve growth factor |
摘要 |
Stable, aqueous pharmaceutical formulations of human nerve growth factor (NGF) in aqueous isotonic solutions, buffered to maintain the pH from about 4.5 to about 6.0, and optionally containing a carrier such as human serum albumin are provided. Also provided are aqueous NGF formulations suitable for lyophilization and subsequent reconstitution in which rhNGF is admixed with sugars, optionally HSA, and buffer. The formulations are useful for the treatment of Alzheimer's disease and other neuronal disorders. |
申请公布号 |
ZA9406333(B) |
申请公布日期 |
1996.02.19 |
申请号 |
ZA19940006333 |
申请日期 |
1994.08.19 |
申请人 |
SYNTEX-SYNERGEN NEUROSCIENCE;JOINT VENTURE |
发明人 |
VICTORIA M KNEPP;DEBORAH M LIDGATE;RICHARD MASKIEWICZ;LEO GU |
分类号 |
A61K9/08;A61K9/00;A61K9/14;A61K9/19;A61K38/18;A61K38/22;A61K47/00;A61K47/02;A61K47/12;A61K47/26;A61K47/42;A61P25/28;C07K |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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