发明名称 |
Linked peptide nucleic acids |
摘要 |
Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other. |
申请公布号 |
AU3196795(A) |
申请公布日期 |
1996.02.16 |
申请号 |
AU19950031967 |
申请日期 |
1995.07.13 |
申请人 |
ISIS PHARMACEUTICALS, INC.;PERSEPTIVE BIOSYSTEMS;DORTE BUCHARDT |
发明人 |
MICHAEL EGHOLM;PETER NIELSEN;OLE +DI BUCHARDT;KIM L DUEHOLM;LEIF CHRISTENSEN;JAMES M COULL;JOHN KIELY;MICHAEL GRIFFITH |
分类号 |
C12N15/09;A61K31/70;A61K31/7088;A61K38/00;A61K47/48;A61K48/00;A61P31/12;A61P35/00;A61P43/00;C07H21/00;C07K1/13;C07K5/06;C07K7/06;C07K7/08;C07K14/00;C12N15/10;C12N15/113;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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