发明名称 |
5'-DITHIO-MODIFIED OLIGONUCLEOTIDES |
摘要 |
The present invention provides nuclease resistant 5'-dithio-modified oligonucleotides that are useful in nucleic acid therapeutics and diagnostics. The novel modified oligonucleotides have at least one 5'-dithioate linkage, wherein both the oxygen atom at the 5'-position (5'-bridging oxygen) and at least one of the non-bridging oxygen atoms of a naturally occurring phosphodiester linkage are independently replaced with a single sulfur atom. The invention also provides a polymer-supported method for making 5'-dithio-modified and 5'-thio-modified oligonucleotides as well as novel monomeric nucleoside and nucleotide intermediates useful in the synthetic method.
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申请公布号 |
CA2195864(A1) |
申请公布日期 |
1996.02.15 |
申请号 |
CA19952195864 |
申请日期 |
1995.07.27 |
申请人 |
AMGEN INC. |
发明人 |
RUSSO-RODRIGUEZ, SANDRA E.;KOGA, TEPPER M. |
分类号 |
C12N15/09;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61K31/7076;A61K31/708;A61K31/7088;A61K48/00;A61P31/12;A61P35/00;C07H19/10;C07H19/20;C07H21/00;C12Q1/68;(IPC1-7):C07H21/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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