发明名称 |
NAPHTHALENE AMIDES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION |
摘要 |
Naphthalene amides of formula (I) wherein the substituent containing A is bound to the 6- or 7- position of the 2-naphthol system; the substituent containing B is bound to the benzene ring at any free position; R<1> is hydrogen or methyl; R<2> is hydrogen, fluorine, chlorine or -OCH3, which is bound to the naphthalene system at any positions except the 2- and the one occupied by the other substituent; R<3> is hydrogen, fluorine, chlorine or bromine; A- is -CO-NR<4>- or -NR<4>-CO- group, wherein R<4> is hydrogen or methyl; B is a 5-tetrazolyl or -COOR<5> group, wherein R<5> is hydrogen, a (C1-C4)-alkyl or a phenylalkyl group of less than 10 carbon atoms; m is 0 or 1; n and p are integers from 0 to 6, with the proviso that n + p is less or equal to 6; as well as the solvates and pharmaceutically acceptable salts thereof, have leukotriene antagonistic action.
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申请公布号 |
WO9604267(A1) |
申请公布日期 |
1996.02.15 |
申请号 |
WO1995EP02970 |
申请日期 |
1995.07.27 |
申请人 |
LABORATORIOS MENARINI S.A.;MAULEON CASELLAS, DAVID;CARGANICO, GERMANO;FOS TORRO, MARIA DE LOS DESAMPARADOS;GARCIA PEREZ, MARIA LUISA;PALOMER BENET, ALBERT |
发明人 |
MAULEON CASELLAS, DAVID;CARGANICO, GERMANO;FOS TORRO, MARIA DE LOS DESAMPARADOS;GARCIA PEREZ, MARIA LUISA;PALOMER BENET, ALBERT |
分类号 |
C07D215/14;C07D215/18;C07D401/12;(IPC1-7):C07D401/12;A61K31/47 |
主分类号 |
C07D215/14 |
代理机构 |
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代理人 |
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地址 |
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