| 摘要 |
<p>The present invention provides a process for making a compound having a structure according to formula (I) wherein A?1, A2 and A3¿ are independently carbon or nitrogen and R?1, R3, R4 and R6¿ are known quinolone substituents; and wherein one of R?1, R3 or R6¿ may be a lactam-containing moiety; or a protected form, salt, pharmaceutically-acceptable salt, biohydrolyzable ester, or solvate thereof; the process comprising reacting one or more organosilicon compounds with a compound having a structure according to formula (II), wherein A?1, A2 and A3, R1, R3, R4 and R6¿ as described above; wherein one of R?1, R3 or R6¿ may be a lactam-containing moiety; and X is a leaving group; or a protected form, salt, biohydrolyzable ester, or solvate thereof. The compounds prepared according to the processes of the invention are themselves useful as antimicrobials, or they may be used as intermediates for making other quinolone-containing antimicrobials.</p> |
